L-arginine gel study

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L-arginine gel study

Postby Fissurefrustration » 18 Dec 2014, 13:17

http://www.ncbi.nlm.nih.gov/pubmed/15747070

anyone seen this? or tried it?

J x
Suffering since June 2013

Methods tried:
GTN cream - migraines!
Manuka Honey / Coconut oil / Aloe
tag excision X 2, botox x 3
Dilatiazem
dilatation 2 X daily + Retin-C Vitamin Scar Treatment Oil 2 X daily - best thing ever.
Now pain free 2/7/21
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Re: L-arginine gel study

Postby former_sufferer » 24 Jul 2015, 11:13

There is now an anal fissure ointment on the market that uses L-arginine as its key ingredient. It's called Analeve. Their website is www.analeve.com.
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Re: L-arginine gel study

Postby msimon » 24 Jul 2015, 11:49

L-Arginine is an amino acid that does the same thing as nitroglycerine as it causes a release of nitrous oxide, a powerful vasodilator. I don't see what it would have to offer over the nitro ointment currently used. Alternatively, you can take it in powder form, orally, but I have read that the doses required for this commonly cause diarrhea. Oral dosing may also cause other systemic side effects such as lightheadedness as it lowers blood pressure.
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Re: L-arginine gel study

Postby former_sufferer » 24 Jul 2015, 15:08

The advantage that the L-Arginine ointment has over the nitroglycerine ointments is that it doesn't cause headaches. From what I've read, some 40% of people who use the nitro ointment get splitting headaches. The study that the original posted cited was for a topical ointment, not something that you orally consume. Analeve is a topical ointment.
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Re: L-arginine gel study

Postby msimon » 24 Jul 2015, 15:55

Headaches were the reason for using Diltiazem and Nifedipine as alternates. I am not convinced that this ointment/gel would be as effective. 15 patients is a very small study and 18 weeks is a long treatment time and 5 times/day application is far too often for most people to maintain. Not sure why there is a search for alternatives when there are already, more effective ones too.
Dec '13 Fissure from anoscope
3 X internal sphincter botox
'08-'15 Botox for pelvic floor dysfunction
Nov '14 LIS/sentinel tag removal
Feb '15 Deroofing of recurrent infection from LIS
summer '15-healed but still ongoing muscle dysfunction/pain
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