Hello, I am a male, 56 years old; have had chronic fissures for over 2 years. I have tried several treatments: Nitroglycerin 0.4% (worked but had severe headaches), Diltiazem 2% (works for me), and Nifedipine 0.2% (didn't work for me). My issue is I use Diltiazem for the recommended 6-8 weeks, then I stop, and within a month after I stop using the Diltiazem the fissures and bleeding returns. I repeat the 6 weeks use of Diltiazem and the bleeding and fissures disappear, but after each 6 week treatment cycle the fissures return within a month. I have been going through this cycle for over 1 and half years. I have not used the Diltiazem past the recommended 8 weeks. Does anyone know the risks or complications of using Diltiazem 2% beyond (longer than) the recommended 6-8 weeks? Are there any studies which have researched the complications or harmful effects when a person continually applies Diltiazem 2% twice a day for longer than 8 weeks?
Any info is appreciated.
Thank you.