Has anyone used Polysporin/Neosporin ointment on their bum and found it relaxed the muscles? I thought I found this before but really noticed it tonight and think there is something to it. Mind you, I have had LIS and find that using things on top of that (as also when I had botox previously) makes thing supercharged, if you will. That is, the relaxing ointments and now I think also antibiotic ointment relaxes the muscles that much further. Just thought I would share and see if anyone was willing to test this out as well.

This is one of the ingredients in this ointment:

http://www.ncbi.nlm.nih.gov/pubmed/194505

http://www.ncbi.nlm.nih.gov/pubmed/191167

http://www.ncbi.nlm.nih.gov/pubmed/219730

http://www.sciencedirect.com/science/ar ... 9981904350

Anyone make sense of this?

The second article is saying something like this:
The polymyxin acted to partially block the effect of stimulating a nerve. They tested this on a preparation where a particular nerve normally causes a muscle contraction. They found that polymyxin B reduced that muscle contraction. The effect was not on the nerve, because the nerve still released acetyl choline. Therefore it worked by blocking the muscle. They proved this by applying the polymyxin, and then squirting acetyl choline onto the muscle, thus bypassing the nerve. The muscle contraction was blocked even more effectively. They think that the mode of action is to make the muscle less sensitive to acetyl choline.

Acetylcholine is normally broken down by cholinesterases. If you block the cholinesterases, this antagonizes the effect of the polymyxin (because now the acetylcholine hangs around for longer).

The other articles seem to say similar things.
Does this make sense? It does say that polymyxin and other similar antibiotics can be muscle relaxants, which I had never heard of before, and sounds like very good news for the likes of us.

Thanks Scientist. Makes more sense now. I got the gist of it but wasn't sure if I was right about the muscle relaxation part. I do think it relaxes things down there and seems to be in addition to the nifedipine. Or maybe that's just me. I found in the 3 rounds of antibiotics I have been on recently that I experienced quite a bit of muscle relaxation/weakness throughout my body and wondered if it would work topically as well.

I hope I read it correctly - I was kind of tired and out of it last night. If it's working for you, that's fantastic!