thanks Scientist, but do fissures occur in the internal anal sphincter?
I thought fissures only cut the mucosal layer, a cut in which may expose the internal anal sphincter.
From my understanding, there are 3 main layers:
1). mucosa (incl. squamous epithelium and various mucosal layers) - this is where fissure occurs
2). internal anal sphincter (involuntary smooth muscle cells, as you said is controlled by the automatic nervous system - this is the layer where LIS aims to cut, but not the layer where fissures necessarily occur)
3). external anal sphincter (voluntary skeletal muscle cells that can be controlled)
I guess since the internal anal sphincter is elastic, it doesn't easily get damaged(or so I hope..?), except when there is an abscess or fistula that penetrates into the sphincter muscles.
I did my last postdoc on a gene that is involved in neurite outgrowth but affect body mass, at some point we were going to look at the enteric nervous system, but in the end we gave up because we knew nothing:P and it's too complicated! (so just a descriptive paper in the end..) These days I am a little obsessed with my AF/Hd problem, I think there should be a journal dedicated to this problem since this is so common.. and painful!!