I have posted multiple times on here about the dramatic effectiveness of an antibiotic: metronidazole 500 suppositories, one a day at bedtime for 10 days. It did not cure my chronic fissure (it kept coming back), but it provided astonishing pain relief almost overnight and helped wound healing as well - i stopped seeing blood after 2 days of use. The fissure was not infected; the use of this antibiotic was more for its anti-inflammatory properties - and, who knows, maybe the antibiotic aspect helped as your link suggests.