Hi sababa-
I didn't use witch hazel wipes, but soaked a cotton pad in witch hazel from the bottle and used that for wiping after a BM or just to be "extra clean" after a shower. I used them maybe 2-3 times a day, and I
did notice irritation. I can't guarantee that it was due to the witch hazel or just because of the fissure itself, but I've been less irritated since I stopped using it and have actually felt darn near perfect the last few days. I might have been using it too often as well.
Give it a try and see if it works for you - a lot of people on the forum here swear by them. And if they don't, well, witch hazel is really good for your face! That's where mine goes now
(although I don't know if I'd use the Prep H wipes on my face...)