I've been trying the Pranicura cream, and find that it does temporarily relieve the itching, burning and discomfort (sometimes known as pruritus ani) that accompanies anal fissure. So far, at any rate, it hasn't made things any worse, and I may continue using it.
The cream's active ingredients are
Glycerin 25%
Kaolin 12.5%
Calamine 12.5%
Menthol 1%
The first three of those ingredients are familiar to me, as my mother used them on us for various purposes as children in Scotland back in the 1950s!