Hi all! I just started applying nitro cream yesterday, this morning was my second application. When I applied it last night it was ok, I didn't notice any unpleasant reaction. But about an hour after applying it this morning I noticed the area was very sore and burning. I feel like the nitro irritated the skin. It's been a few hours now, and it's better. But not fully gone. Has anyone else experienced this?

Hi!

When my fissure was at its worst, so in the beginning I noticed this and sometimes it would last all day! But as healing has occurred the burning is a lot less, I just persevered, but everyone may be different!

Nitro caused burning for me every single time I used it. I found nifedipine caused no irritation at all and helped with spasms.