Botox

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Botox

Postby Guest » 06 Nov 2008, 08:53

Botulinum Toxin Type A.
For the treatment of chronic anal fissure†, an initial total dose of 5–20 units of botulinum toxin type A generally has been used. Injections should be made both lateral and distal to the fissure; local anesthesia before injection generally does not appear to be necessary. Either the internal or external anal sphincter may be injected with the toxin; the optimal injection site has not been determined. Some clinicians state that that injection of the internal sphincter is preferable because of the role of internal sphincter spasm in chronic anal fissure and the fact that it is it is easily palapated and injected; however, other clinicians prefer injection of the external sphincter because injection in this area allows diffusion of the toxin to the internal sphincter, while localization of botulinum toxin type A in the internal anal sphincter is not always possible and may allow diffusion of the drug into the intrasphincteric space, which may result in fecal and/or flatulence incontinence. Some clinicians state that injection into the puborectalis muscle (caused by too deep an injection) should be avoided as it may be associated with a high risk of incontinence.
Following injection of botulinum toxin type A in patients with chronic anal fissure, a reduction in pain has been reported within 2 days and sphincter tone is reduced for 4 weeks or longer. Limited data suggest that healing rates may be higher with higher doses. Repeat injections using the same initial dose or a higher dose appear to be safe and effective in patients who fail to heal after the initial injection or who have relapses.
http://www.medscape.com/druginfo/monographcid=med&drugid=9827&drugname=Botox+IM&monotype=monograph&secid=4
http://books.google.co.uk/books?id=2qT6cc-EPtIC&pg=PA95&dq=2.5+units+botox+anal+fissure
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Re: Botox

Postby cherylk » 06 Nov 2008, 08:58

I think as more and more people get Botox, the Botox regimen will probably be refined as doctors learn more about the best way and the best amount.
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Re: Botox

Postby Deleted User 5 » 06 Nov 2008, 12:45

Maybe one day they'll have botox suppository!
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Re: Botox

Postby cherylk » 06 Nov 2008, 12:47

Well, if they can make brain cells from stem cells like I just read about this morning, we have to think that anything is possible. If Botox can be injected, why couldn't it be placed in a suppository??? It would probably be a lot more comfortable way of absorbing the botulism toxin (especially if one is awake)!!!
Last edited by cherylk on 06 Nov 2008, 13:38, edited 1 time in total.
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Re: Botox

Postby Guest » 06 Nov 2008, 13:12

Ahh botox suppository........Sounds like heaven Image
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